San Francisco 49ers vs. Arizona Cardinals Prediction and Picks - January 5, 2025

In a clash of two NFC West rivals already out of the playoff picture, the San Francisco 49ers (6-10) will take on the Arizona Cardinals (7-9) at State Farm Stadium. The teams previously met on October 6th, with the Cardinals narrowly winning 24-23. As they face off again, both squads aim to finish the season on a high note, setting a positive tone for the upcoming year. Brock Purdy has been ruled out for the 49ers in Week 18, emphasizing the importance of this matchup despite the lack of playoff implications.

The 49ers’ Rollercoaster Season

The 49ers are reeling from a disappointing Monday Night Football defeat to the Detroit Lions, marking their sixth loss in seven games. This season has not met the high expectations set before it, leaving the team with a disappointing 6-10 record. Offensively, the 49ers rank 7th in total yards per game (382.7) and 6th in passing yards (256.1 PYPG). Quarterback Brock Purdy has amassed 3,864 passing yards and thrown 20 touchdowns. However, his 12 interceptions have contributed to the team’s struggles. The rushing attack, spearheaded by Jordan Mason’s 789 rushing yards, ranks 11th with an average of 126.6 rushing yards per game. Reliable tight end George Kittle has notched 1,079 receiving yards, while Jauan Jennings has stepped up with a career-high 923 receiving yards.

Defensively, the 49ers have faced challenges, yet Nick Bosa’s nine sacks in 13 games provide a glimmer of hope. Linebacker Fred Warner leads the team’s defense with 123 total tackles and two interceptions, but overall, the unit has not performed as expected.

Cardinals’ Promising Start Turns Sour

The Arizona Cardinals began the season with promise, surpassing early expectations. However, they have stumbled recently, losing five of their last six games. Their offense ranks 11th in total yards per game (369.8), bolstered by a strong running game that sits at 7th with an average of 143.8 rushing yards per game. Quarterback Kyler Murray has rebounded well, throwing for 3,609 yards and adding 550 rushing yards while playing in all 16 games. Running back James Conner has been a key contributor, rushing for 1,094 yards and providing stability to the offense.

Rookie tight end Trey McBride has emerged as a standout player, leading the team with 1,081 receiving yards. First-round draft pick Marvin Harrison Jr. has also impressed, recording 822 yards and seven touchdowns in his debut season.

On the defensive side, the Cardinals rank 18th in total yards allowed per game (336.7). Safety Budda Baker has been a standout, leading the squad with 155 total tackles. However, the pass rush has been a concern, with Dante Stills managing to lead the team with only 4.5 sacks.

Best Bets for the 49ers vs. Cardinals Showdown

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