2025 college football odds are shaping up as the excitement builds for the upcoming season. The 2024 college football season concluded with Ohio State triumphing over Notre Dame, clinching the Playoff title in the first year of the expanded 12-team format.
While the Buckeyes are basking in their glory, fans are already eager to focus on the thrilling matchups that await in the next season.
In this spirit, let’s explore the betting lines and spreads for several exciting games set for Week 1 of the 2025 college football season, as provided by FanDuel on January 22.
(All times, TV TBD)
SAT, AUG. 30
Texas @ Ohio State
What to know: This matchup features two powerhouse teams that finished the previous season in the top five, with Ohio State claiming the No. 1 spot after their national title victory and Texas holding steady at No. 4 after their semifinal defeat to OSU. The Buckeyes are favored to defend their championship, bolstered by the return of standout wide receiver Jeremiah Smith. Both squads are expected to debut new starting quarterbacks, with Arch Manning stepping in for Texas.
Notre Dame @ Miami (FL)
What to know: Notre Dame finished the season ranked No. 2, while Miami landed at No. 18. The Fighting Irish will retain a significant portion of their roster, whereas the Hurricanes will need to adjust after losing projected No. 1 pick Cam Ward. They will welcome former Georgia quarterback Carson Beck, which could provide a solid new direction for their offense.
LSU @ Clemson
What to know: Clemson reached the College Football Playoff after securing the ACC Championship, finishing the season at No. 14. In contrast, LSU struggled, failing to make the top 25 after losing three of their last five games. Clemson quarterback Cade Klubnik returns after an impressive season, throwing for 3,639 yards, 36 touchdowns, and just six interceptions, a promising sign for the Tigers.
Alabama @ Florida State
What to know: Florida State faced a challenging season, finishing with a disappointing 2-11 record after a stellar 13-0 campaign the previous year. The Seminoles will need to find a new quarterback. Meanwhile, Alabama narrowly missed the College Football Playoff, finishing ranked No. 17 after setbacks against Vanderbilt and Oklahoma. Year two under coach Kalen DeBoer brings heightened expectations for the Crimson Tide.
